There is ongoing discussion about cold chain requirements of multiple Covid vaccines in development. Vaccines have different storage temperatures. Some mRNA vaccines have extremely low storage temperatures, but can apparently used for a few days under regular vaccine distribution temperatures of 2 to 8°, after thawing. Understanding these requirements is important to estimate the feasibility of vaccines in various parts of the world. The attached poster has a summary as of 22 November 2020.
In our experience at Government Medical College Ernakulam, we have come across patients with typical radiological features of COVID-19 but the RTPCR is negative. They have classical CT chest findings, clinical features and viral blood picture. Therefore, just as we make a diagnosis of Smear negative pulmonary Tuberculosis, we should be aware of the entity RTPCR negative COVID-19. RTPCR could be negative due to many reasons. If we fail to acknowledge this entity, we might miss the diagnosis on several cases of SARS-CoV-2 infection. Prof. A. Fathahudeen, Head of Pulmonology, GMC Ernakulam
The following protracted symptoms were observed in COVID19 patients after their RTPCR test became negative and after their so-called test-recovery. Anosmia, abdominal symptoms including diarrhoea for a couple of weeks, chronic fatigue and anxiety were reported. The recovery period, viral clearance and the time taken to convert to negative varied from person to person, averaging between 2 weeks to 50 days. It is proposed that all these symptoms constitute the post Corona recovery syndrome. Prof.A. Fathahudeen, Head of Pulmonology, GMC Ernakulam
59 yr old man with no co-morbid illness. Travel to Wayanad; followed by fever - day 9 at presentation. Initiated on Piptaz by primary care doctor. Persistent fever, progressive renal failure and then maculo-papular truncal rash. Stopped Piptaz, started on Doxycycline with full recovery. Scrub IgM +
Elderly lady with fever and loose stools of 3 days. Preceded by having food from marriage function. Referred after failure to respond on Ciprofloxacin and Metronidazole. Initiated on Ceftriaxone. Blood culture shows Salmonella species on day 2.